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KMID : 0385020030190010039
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Korean Journal of Laboratory Animal Science
2003 Volume.19 No. 1 p.39 ~ p.44
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Studies of the Basic Data of Dominant Hair-poor Mice derived from ENU-mutagenesis
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조규혁/Cho, Kyu-Hyuk
남윤이/조재우/이필수/한상섭/송창우/Nam, Yoon-Yi/Cho, Jae-Woo/Lee, Phil-Soo/Han, Sang-Seop/Song, Chang-Woo
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Abstract
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Mutant mice with hair % skin anomaly were observed from ENU mutagenesis program. This study was carried out to identify inheritance, incidence and general characteristics such as reproduction, body weight through mating experiment and gross observation. This mutant mouse has been detected in the first generation after ENU-treated BALB/c male. It was possible to distinguish mutant from normal littermates after 1 week old because it exhibited poor % short hair of whole body. Affected mice weighted about 15% less than normal littermates at 3 weeks old. When the poor % short hair mouse was crossed with phenotypic normal mouse, the incidence was 56, 48 and 65% in the G_3, G_4, and G_5, respectively, and totally 61% from G_2 to G_6 generation. The segregation ratio of the normal and the mutant was close to 1:1 (p>0.05). Each number of the mutant males and females was totally 88 and 101, respectively and the sex ratio was 1 : 1 (p>0.05). Therefore it is supposed that this mutation be transmitted next generation by autosomal dominant mode. Average of pups and weanlings rate was 5.8 heads and 94.7%, respectively. Reproductive performance of mutants was not different from that of normal BALB/c.
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